This year Dr. Riddiford published a JH review in Journal of Insect Physiology (JIP). Take a look at it and you may get some ideas about future JH research. Looks like she think Met is at the top of JH signal transduction cascade, although more evidences needed to prove that Met is a JH receptor.
What is interesting to me is her comments on Dr. Yiping Li's JBC paper. She said, "This model (Dr. Li's model) is greatly oversimplified and ignores the fact that 20E directs and coordinates
nearly the same TF cascade during a molt, irrespective of whether or not JH is present, with only a few metamorphic-specific genes such as broad being induced at the time of metamorphosis in the absence of JH...... The indication from all these studies of JH-regulated
genes with different putative JHREs suggests that in addition to a ''JH receptor'', there is likely a myriad of interacting factors that can modulate the final outcome."
Maybe JH action IS really a complicate biological process......
No comments:
Post a Comment